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Tracxn – Analyst Notes # 1321 – Biopharma (by Disease)

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Funding Rounds

Post IPO, $850M
Nektar (1990, San Carlos) – Novel therapeutics based on advanced polymer conjugate chemistry technology platform

Post IPO, $300M
Kite Pharma (2009, Los Angeles, $100.3M) – Develops cancer immunotherapy products using genetic engineering

Series E, $100M
Constellation Pharma (2008, Cambridge, $348.6M) – Discovers and develops drugs in the field of epigenetics.

Investors: Deerfield, Fidelity Investments, Hillhouse Capital Group, Orbimed, SIRONA CAPITAL, Venrock, The Column Group, Third Rock Ventures, SR One, Casdin Capital, Topspin Partners, University of California Office of the President

Series B, $70M
Crescendo (2009, Cambridge, $109M) – Humabodies and conjugates to treat psoriasis and prostate cancer.

Investors: anderapartners.com, Sofinnova Partners, IP Group, Takeda Ventures, Quan Capital, EMBL Ventures

Series B, $64M
Eidos Therapeutics (2016, Palo Alto, $64M) – small-molecule treatment for transthyretin (TTR) amyloidosis.

Investors: RA Capital Management, Janus Henderson Investors, Viking Global Investors, Aisling Capital, Perceptive Advisors, Amzak Capital Management, BridgeBio

Series B, $60M
Corvidia Therapeutics (2016, Waltham, $86M) – Cardiovascular therapies leveraging functional genomics.

Investors: Venrock, anderapartners.com, HBM Healthcare Investments, Apple Tree Partners, MedImmune, Sofinnova Ventures, Fresenius Medical Care

Series B, $56M
Revolution Medicines (2014, Redwood City, $126M) – Discovering and developing novel anti-cancer targeted small molecule drugs.

Investors: Nextech Invest, Casdin Capital, Schroder Adveq, The Column Group, Third Rock Ventures

Series C, $55M
Arvinas (2013, New Haven, $111.6M) – Small molecule drugs to target and degrade disease causing proteins

Investors: Nextech Invest, Deerfield, Hillhouse Capital Group, SIRONA CAPITAL, Canaan Partners, 5AM Ventures, RA Capital Management, Orbimed, New Leaf Venture Partners

Series C, $52M
Magenta Therapeutics (2016, Cambridge, $150.5M) – Stem cell-based therapies for autoimmune disease, genetics blood disorders and cancer

Investors: Casdin Capital, EcoR1 Capital, Eventide Funds, bethematchbiotherapies.com, Access Industries

Series C, $50M
Tessa Therapeutics (2011, Singapore, $130M) – T Cell-based therapies for virus-related cancers.

Investors: Temasek, EDBI, Heliconia Capital Management, heritascapital.com

Post IPO, $50M
Prothena (2012, Dublin) – Antibodies for the treatment of AL amyloidosis, Parkinson’s disease and psoriasis.


Venture Debt, $45M
Omeros (1994, Seattle, $66.9M) – Small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, coagulopathies and CNS disorders

Investors: CRG

Post IPO, $44.5M
Inventiva Pharma (2011, Daix) – Small molecules for the treatment of NASH, Systemic sclerosis, Mucopolysaccharidoses (rare disease) and cancers.

Investors: BVF Partners, Novo Holdings, Sofinnova Ventures

Series B, $41.1M
Enterprise Therapeutics (2014, Brighton, $53.0M) – Therapies for treatment of respiratory diseases such as cystic fibrosis.

Investors: Versant Ventures, Novartis Venture Fund, Forbion Capital Partners, Epidarex Capital, IP Group

Post IPO, $38.7M
Tracon Pharma (2005, San Diego, $50.5M) – Antibody therapeutics for cancer and fibrotic diseases.

Investors: Puissance Capital Management, New Enterprise Associates

M&A

  • Novartis bets big on gene therapy with $8.7 billion AveXis deal Reuters
  • Advent is said to near deal to acquire Sanofi Generics unit Livemint
  • Biotech M&A rolls on as Alexion snaps up Wilson for $855 million Reuters
  • HCL Technologies Acquires Life Sciences and Consumer Services Provider C3i Solutions Business Wire
  • Fresenius pulls out of Akorn takeover over data integrity Reuters
  • Ferring Acquires Innovative Biotechnology Company and Microbiome Pioneer Rebiotix Inc. Business Wire
  • Avara Pharmaceutical Services Finalizes Acquisition of GSK Consumer Healthcare facility in South Carolina PR Newswire
  • Mylan to buy MS drug marketing rights from Israel’s Mapi Pharma Reuters
  • Corona Remedies acquires two brands from Abbott Indiatimes
  • Inception Neuroscience Program Acquired by Roche Business Wire

IPO

  • Unity Biotech Files IPO to Bring Anti-Aging Drugs into Clinical Trials Xconomy
  • Flagship’s Evelo Biosciences pitches $100M IPO for a new platform of monoclonal microbials EndPoints News
  • MorphoSys Resolves a Capital Increase to Implement the Offering of 8,300,000 American Depositary Shares (ADS) in the United States Life-Sciences-Germany
  • Alzheon Launches Roadshow for Initial Public Offering Business Wire
  • Abpro planning $69M NASDAQ listing BioCentury
  • Mereo BioPharma’s Rationale for Halting IPO Draws Skepticism BioSpace
  • Arcus Biosciences’ $138 Million Initial Public Offering Global Legal Chronicle
  • Surface Oncology reaches public markets in $108m IPO Global Corporate Venturing
  • Menlo’s IPO hangover begins with a failed PhII for an old Merck castoff EndPoints News
  • Unity Biotech Announces Potential Pricing for IPO Wall

Funds Raising Funds

  • AXIM Biotech Secures Additional Funding to Advance Cannabidnoid-Based Clinical Development Program for Multiple Indications EconoTimes

FDA Approval

  • FDA refuses to review Alkermes’ depression treatment, seeks more trials Reuters
  • FDA approves Ultragenyx’s drug for rare form of rickets Reuters
  • GW cannabis-derived epilepsy drug gets positive FDA staff review Reuters
  • Rigel Website Shows Erroneous Information that Tavalisse Has Been Approved by the FDA BioSpace
  • Dr. Reddy’s Laboratories and its U.S. subsidiary Promius Pharma announce the filing of an NDA for its migraine candidate Business Wire
  • Pfizer Granted FDA Breakthrough Therapy Designation for TRUMENBA® (Meningococcal Group B Vaccine) for the Prevention of Invasive Meningococcal B Disease in Children Ages 1 to 9 Years Business Wire
  • Glenmark gets USFDA nod for skin ointment Livemint
  • US FDA Accepts Biologics License Application for Moxetumomab Pasudotox in Hairy Cell Leukemia Business Wire

Regulatory Change

New Product Announcement

  • ‘Site-less’ trials in mind, Novartis launches an app for ophthalmology research EndPoints News
  • Acerus Announces Launch of URIVARX® in Canada Business Wire
  • Natco Pharma launches 1st generic version of Oral tablets for Multiple Sclerosis Business Standard
  • Basilea reports launch of antibiotic Zevtera (ceftobiprole) in Canada by Avir PharmaGlobeNewswire
  • Look at our new launches, GSK urges, as its respiratory woes steal the limelightFiercePharma
  • Alcon introduces pre-loaded delivery system for the CyPass® Micro-Stent to enhance surgical experience PR Newswire
  • Innovus Pharma Announces the Launch of its Hemorrhoid Drug Xyralid® in CanadaBioSpace

New Geo Entry

Business Partnership

  • Ionis may get up to $300 million in licensing deal with AstraZeneca Reuters

Company Announcement

Earnings Release

  • Pampg Quarterly Results Surpass Estimates News Amed

Research Partnership

  • Pfizer in deal with Allogene to develop cancer cell therapies Reuters
  • Biogen boosts investment in neurology with $1 billion Ionis deal Reuters
  • Loxo, Illumina to partner for diagnostic tool targeting cancer Reuters
  • Bristol-Myers Squibb Announces Worldwide Collaboration with Janssen to Develop and Commercialize Next-Generation Cardiovascular Therapy Business Wire
  • Boehringer Ingelheim and OSE Immunotherapeutics Announce Global Immuno-Oncology Partnership to Develop a Pioneering Checkpoint Inhibitor for the Treatment of Advanced Solid Tumors Business Wire

Lawsuit

  • Samsung Bioepis goes to courts to defeat AbbVie patents covering Humira theinvestor.co.kr
  • Brower Piven Reminds Shareholders Of Approaching Deadline In Class Action Lawsuit And Encourages Investors Who Have Losses In Excess Of $100,000 From Investment In Bellicum Pharmaceuticals, Inc. (Nasdaq: BLCM) To Contact The Firm GlobeNewswire

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